Some unsolicited opinions...

More users are jumping on the 64-bit bandwagon, and the 64 Studio developers are doing their best to make the ride as smooth as possible.
Dave Phillips, Linux Journal

I am using 64 Studio based systems since more than a year for my everyday media production work, sound recording, sound design and video editing without any significant system related problems. And for the smaller issues, I always found quick help and a friendly community.
Hermann Vosseler

It's the most polished, complete, stable and easy to setup GNU/Linux I've used for audio work.
Michael Pacey

I have to say again, this machine *smokes* now. Last night I worked with the Pd/GEM combo, putting videos on the surface of a rotating cube, with not a single xrun (at sub-6ms latency). Ditto while working with Oyvind Brandtseg's powerful ImproSculpt, an amazing realtime instrument based on Csound5 and its FLTK widgets. Again, perfect performance.
Dave Phillips (again)

Debian-based 64 Studio, which has just achieved its 1.0 release, is described by some as "the best distribution ever created for multimedia workstations, such as digital audio recording and video editing."
Steven J. Vaughan-Nichols, Desktop Linux

I must say this is the best linux multimedia distro out there. 64 studio found all my soundcards and configured properly from install, even my photon x25 which has ben a problem in the past. I have been getting my best jack performance I have ever seen (down to .667 ms at 96khz) with very little x runs at app start.
Nate Figlar

All I had to do was to change the number of input and output channels to eight each, set the sample rate to 96KHz and set the latency as low as it would go. It hasn't under-run since, and performs so well it regularly saturates the hard disk.
Amias Channer, Linux Format magazine, issue 97

For a production environment, we would suggest you go for 64 Studio (www.64studio.com). This has a custom-configured, multimedia kernel, compiled for AMD 64-bit and Intel EM64T processors and will handle dual-core processors as well. In addition, it has the stability and security of Linux – and, it’s free.
Paul Grosse, PC Plus magazine, issue 257

...a great looking system that squeezes every ounce of performance out of my hardware and works like a dream.
Sam Banks, Linux Forums

...if you’re curious about building a Linux workstation specifically for multimedia creation and want a distribution that has most of the important stuff already there, give this one a whirl.
Serdar Yegulalp, Information Week

64 Studio 2.0... is based on the current stable branch of one of the largest and most popular Linux distributions, Debian 4.0 "Etch". Thus 64 Studio can be extended simply, with further programs from the enormous Debian repertoire.
Klaus Gürtler, Der Spiegel (translated from German)